{"id":739,"date":"2013-02-20T13:25:21","date_gmt":"2013-02-20T04:25:21","guid":{"rendered":"http:\/\/www.heimat-ltd.com\/cn\/?p=739"},"modified":"2021-02-22T12:24:18","modified_gmt":"2021-02-22T03:24:18","slug":"angiogenesis-in-cancer","status":"publish","type":"post","link":"https:\/\/www.heimat-ltd.com\/cn\/information\/articles\/angiogenesis-in-cancer.html","title":{"rendered":"\u8840\u7ba1\u65b0\u751f\u548c\u764c\u75c7"},"content":{"rendered":"
\r\n

\u8840\u7ba1\u65b0\u751f\u548c\u764c\u7684\u751f\u9577\u53ca\u8f49\u79fb<\/h2>\r\n

\u8840\u7ba1\u65b0\u751f\u5c0d\u60e1\u6027\u816b\u7624\uff08\u764c\uff09\u7684\u751f\u9577\u8d77\u8457\u6c7a\u5b9a\u4f5c\u7528\u3002\u4e00\u65b9\u9762\u65b0\u8840\u7ba1\u4fdd\u8b49\u4e86\u764c\u7d30\u80de\u7684\u6c27\u4f9b\u3001\u71df\u990a\u53ca\u4ee3\u8b1d\u7523\u7269\u7684\u6392\u6cc4\u4ee5\u4fc3\u9032\u5176\u751f\u9577;\u53e6\u4e00\u65b9\u9762\u764c\u7d30\u80de\u53c8\u501f\u52a9\u65b0\u8840\u7ba1\u5411\u8eab\u9ad4\u5176\u4ed6\u90e8\u5206\u8f49\u79fb\u3002\u816b\u7624\u525b\u5f62\u6210\uff0c\u5927\u5c0f\u4e0d\u8d85\u904e1\uff5e2\u33a3\u6642\uff0c\u4e0d\u9700\u8981\u65b0\u751f\u8840\u7ba1\uff0c\u764c\u7d30\u80de\u53ea\u9700\u76f4\u63a5\u5438\u6536\u5468\u906d\u74b0\u5883\u7684\u990a\u4efd\u5373\u53ef\u5b58\u6d3b\u3002\u8d85\u904e1\uff5e2\u33a3\u7684\u764c\u7d44\u7e54\u5c31\u5fc5\u9808\u9760\u65b0\u751f\u8840\u7ba1\u4f86\u4f9b\u61c9\u990a\u4efd\u3002\u5c0d\u65bc\u9019\u6a23\u7684\u60e1\u6027\u816b\u7624\uff0c\u53ea\u8981\u80fd\u5920\u6291\u5236\u8840\u7ba1\u65b0\u751f\uff0c\u5207\u65b7\u60e1\u6027\u816b\u7624\u7684\u71df\u990a\u4f9b\u7d66\u4f86\u6e90\uff0c\u5c31\u53ef\u4ee5\u8b93\u816b\u7624\u9913\u6b7b\u3002<\/p>\r\n

\u8840\u7ba1\u5167\u76ae\u6210\u9577\u56e0\u5b50(VEGF) \u7531\u764c\u7d30\u80de\u7b49\u5206\u6ccc\u7522\u751f\uff0c\u5177\u6709\u8a98\u5c0e\u8840\u7ba1\u65b0\u751f\u7684\u4f5c\u7528\u3002VEGF\u901a\u904e\u8207\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u7d50\u5408\uff0c\u523a\u6fc0\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u6d3b\u5316\u3001\u589e\u6b96\u548c\u9077\u79fb\uff0c\u4fc3\u9032\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u3002<\/p>\r\n<\/div>\r\n

\r\n

\u63a7\u5236\u65b0\u751f\u8840\u7ba1\u5c0d\u6cbb\u7642\u764c\u75c7\u7684\u4f5c\u7528<\/h2>\r\n

\u4e0a\u4e16\u7d0070\u5e74\u4ee3\u521d\u671f\uff0c\u54c8\u4f5b\u5927\u5b78\u7684Judah Folkman\u535a\u58eb\u5c31\u5efa\u8b70\u91c7\u7528\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291\u63a7\u5236\u65b0\u751f\u8840\u7ba1\u7684\u751f\u9577\u53bb\u6cbb\u7642\u5404\u7a2e\u764c\u75c7\uff0c\u525d\u596a\u764c\u7d30\u80de\u7684\u6c27\u6c23\u548c\u990a\u5206\u4f9b\u61c9\uff0c\u540c\u6642\u4f7f\u4e4b\u7523\u751f\u7684\u4ee3\u8b1d\u7523\u7269\u5806\u7a4d\uff0c\u8fd1\u800c\u63a7\u5236\u764c\u7d30\u80de\u7684\u751f\u9577\u548c\u8f49\u79fb\u3002<\/p>\r\n<\/div>\r\n

\r\n

\u4e3b\u8981\u904e\u7a0b\u5982\u4e0b<\/h3>\r\n
    \r\n
  1. \u6291\u5236\u8840\u7ba1\u751f\u6210\u4fc3\u9032\u56e0\u5b50\u7684\u7523\u751f<\/li>\r\n
  2. \u6291\u5236\u964d\u89e3\u9176\u7684\u7523\u751f<\/li>\r\n
  3. \u6291\u5236\u8840\u7ba1\u58c1\u7d30\u80de\u5206\u88c2\u589e\u751f<\/li>\r\n
  4. \u6291\u5236\u8840\u7ba1\u58c1\u7d30\u80de\u79fb\u52d5<\/li>\r\n
  5. \u6291\u5236\u8840\u7ba1\u58c1\u7d30\u80de\u6d3b\u5316<\/li>\r\n <\/ol>\r\n<\/div>\r\n
    \r\n \u53c3\u8003\u6587\u737b<\/b>\r\n
      \r\n
    1. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol, 2002 Dec 29 (6 Suppl 16), 15-8<\/li>\r\n
    2. Daly ME; Makris A; Reed M; Lewis CE. Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment?. J Natl Cancer Inst 2003 Nov 19, 95(22), 1660-73.<\/li>\r\n
    3. Heath VL; Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009 Jul 6(7), 395-404.<\/li>\r\n
    4. Chung AS; Lee J; Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer 2010 Jul, 10(7), 505-514.<\/li>\r\n
    5. Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008 Aug;8(8):579-591. doi: 10.1038\/nrc2403.<\/li>\r\n
    6. Zeng G, Taylor SM, McColm JR, Kappas NC, Kearney JB, Williams LH, Hartnett ME, Bautch VL. Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Blood. 2007 Feb 15;109(4):1345-1352<\/li>\r\n
    7. Hidalgo M, Eckhardt SG. Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 2001 Feb 7;93(3):178-193.<\/li>\r\n
    8. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug;8(8):604-617. doi: 10.1038\/nrc2353.<\/li>\r\n
    9. Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin. 2010 Jul-Aug;60(4):222-43. doi: 10.3322\/caac.20075.<\/li>\r\n
    10. In-sook Ahn; Steven Grekin; Stephen Verral; John Croft. An Ethanolic extract from a shark having potent anti-angiogenic activity: its anti-angiogenic mechanism and clinical application. Poster session: March 9, 2006 San Diego, California, U.S.A.<\/li>\r\n
    11. Satoru Furukawa. Shark lipids for malignant diseases. December 12, 2005 Annual Meeting of Korean Society of Cancer Prevention.<\/li>\r\n <\/ol>\r\n<\/div>","protected":false},"excerpt":{"rendered":"\u8840\u7ba1\u65b0\u751f\u5c0d\u60e1\u6027\u816b\u7624\uff08\u764c\uff09\u7684\u751f\u9577\u8d77\u8457\u6c7a\u5b9a\u4f5c\u7528\u3002\u4e00\u65b9\u9762\u65b0\u8840\u7ba1\u4fdd\u8b49\u4e86\u764c\u7d30\u80de\u7684\u6c27\u4f9b\u3001\u71df\u990a\u53ca\u4ee3\u8b1d\u7523\u7269\u7684\u6392\u6cc4\u4ee5\u4fc3\u9032\u5176\u751f\u9577;\u53e6\u4e00\u65b9\u9762\u764c\u7d30\u80de\u53c8\u501f\u52a9\u65b0\u8840\u7ba1\u5411\u8eab\u9ad4\u5176\u4ed6\u90e8\u5206\u8f49\u79fb\u3002","protected":false},"author":52,"featured_media":1535,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[51],"tags":[],"class_list":["post-739","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/comments?post=739"}],"version-history":[{"count":8,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/739\/revisions"}],"predecessor-version":[{"id":1627,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/739\/revisions\/1627"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/media\/1535"}],"wp:attachment":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/media?parent=739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/categories?post=739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/tags?post=739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}