{"id":768,"date":"2013-04-20T09:41:00","date_gmt":"2013-04-20T00:41:00","guid":{"rendered":"http:\/\/www.heimat-ltd.com\/cn\/?p=768"},"modified":"2021-02-22T12:23:23","modified_gmt":"2021-02-22T03:23:23","slug":"angiogenesis-and-skin","status":"publish","type":"post","link":"https:\/\/www.heimat-ltd.com\/cn\/information\/articles\/angiogenesis-and-skin.html","title":{"rendered":"\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u75be\u75c5"},"content":{"rendered":"<div class=\"details_box\">\r\n  <p>\u8840\u7ba1\u65b0\u751f\u53ef\u5c0d\u76ae\u819a\u5e36\u4f86\u5404\u7a2e\u751f\u7406\u53ca\u75c5\u7406\u7684\u5f71\u97ff\uff0c\u5982\u76ae\u819a\u8001\u5316\u3001\u66ec\u50b7\u3001\u5275\u50b7\u6cbb\u6108\u3001\u725b\u76ae\u766c\u3001\u6fd5\u75b9\u3001\u8840\u7ba1\u7624\u3001\u8840\u7ba1\u7e96\u7dad\u7624\u3001\u5361\u6ce2\u897f\u8089\u7624\u7b49\u7b49\u3002\u6211\u5011\u7684\u76ae\u819a\u6bcf\u5929\u66b4\u9732\u5728\u65e5\u5149\u4e4b\u4e0b\uff0c\u9577\u671f\u53d7\u5230\u7d2b\u5916\u7dab(UV)\u548c\u7d05\u5916\u7dab\u7684\u523a\u6fc0\uff0c\u800c\u6b63\u662f\u9019\u4e9b\u523a\u6fc0\u5c0e\u81f4\u76ae\u819a\u65b0\u751f\u8840\u7ba1\u7684\u5f62\u6210\u3002<\/p>\r\n  <div class=\"fig_box\">\r\n    <div class=\"fig_title\">\u57161. \u7531\u7d2b\u5916\u7dab\u5f15\u8d77\u7684\u8840\u7ba1\u751f\u6210\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u75be\u75c5<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.heimat-ltd.com\/cn\/wp-content\/uploads\/research_angiogenesis_skin_01.jpg\" alt=\"\u7531\u7d2b\u5916\u7dab\u5f15\u8d77\u7684\u8840\u7ba1\u751f\u6210\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u75be\u75c5\">\r\n  <\/div>\r\n<\/div><!--details_box-->\r\n<div class=\"details_box\">\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u5149\u8001\u5316<\/h2>\r\n  <p>\u76ae\u819a\u5149\u8001\u5316\u662f\u6307\u76ae\u819a\u9577\u671f\u66b4\u9732\u5728\u7d2b\u5916\u7dab\u4e0b\uff0c\u4fc3\u4f7f\u76ae\u819a\u904e\u65e9\u7684\u51fa\u73fe\u8001\u5316\u6027\u6539\u8b8a\u3002\u7d2b\u5916\u7dab\u8f3b\u5c04\u5c0e\u81f4\u76ae\u819a\u7d30\u80de\u7522\u751f\u708e\u75c7\u3001\u8a98\u5c0e\u6d3b\u6027\u6c27\u7522\u751f\u3001\u4fc3\u9032\u7d30\u80de\u5916\u57fa\u8cea\uff08\u81a0\u539f\u86cb\u767d\u7b49\uff09\u964d\u89e3\uff0c\u9020\u6210\u76ae\u819a\u751f\u6210\u76ba\u7d0b\u3001\u9ed1\u8272\u7d20\u6c88\u8457\u3002\u8207\u6b64\u540c\u6642\uff0c\u7d2b\u5916\u7dab\u8f3b\u5c04\u5c0d\u76ae\u819a\u8840\u7ba1\u4e5f\u9020\u6210\u5f71\u97ff\uff0c\u4fc3\u9032\u76ae\u819a\u5f62\u6210\u65b0\u751f\u8840\u7ba1\u3002\u56e0\u7232\u76ae\u819a\u5149\u8001\u5316\u548c\u8840\u7ba1\u65b0\u751f\u5169\u8005\u6709\u8457\u5f88\u6df1\u7684\u95dc\u4fc2\uff0c\u6240\u4ee5\u6291\u5236\u76ae\u819a\u5f62\u6210\u65b0\u751f\u8840\u7ba1\uff0c\u53ef\u9810\u9632\u6216\u5ef6\u7de9\u5149\u8001\u5316\u7684\u9032\u7a0b\u3002<a href=\"https:\/\/www.heimat-ltd.com\/cn\/research\/anti-angiogenesis\/wringle-angiogenesis.html\" title=\"\u8840\u7ba1\u65b0\u751f\u548c\u76ba\u7d0b\">\u6709\u95dc\u76ba\u7d0b\u8840\u7ba1\u76f8\u95dc\u4fe1\u606f\uff0c\u8acb\u9ede\u64ca\u6b64\u8655&gt;&gt;<\/a><\/p>\r\n  <div class=\"fig_box\">\r\n    <div class=\"fig_title\">\u57162\uff0e\u7d2b\u5916\u7dab\u7167\u5c04\u5f15\u8d77\u5c0f\u9f20\u76ae\u819a\u7522\u751f\u76ba\u7d0b\u4ee5\u53ca\u5f62\u6210\u8840\u7ba1\u751f\u6210\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u75be\u75c5<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.heimat-ltd.com\/cn\/wp-content\/uploads\/research_angiogenesis_skin_02.jpg\" alt=\"\u7d2b\u5916\u7dab\u7167\u5c04\u5f15\u8d77\u5c0f\u9f20\u76ae\u819a\u7522\u751f\u76ba\u7d0b\u4ee5\u53ca\u5f62\u6210\u8840\u7ba1\u751f\u6210\u8840\u7ba1\u65b0\u751f\u548c\u76ae\u819a\u75be\u75c5\">\r\n  <\/div>\r\n<\/div><!--details_box-->\r\n<div class=\"details_box\">\r\n  <h2>\u8840\u7ba1\u65b0\u751f\u548c\u725b\u76ae\u766c<\/h2>\r\n  <p>\u725b\u76ae\u766c\u662f\u4e00\u7a2e\u4f34\u96a8\u6709\u8840\u7ba1\u65b0\u751f\u7684\u708e\u75c7\u6027\u76ae\u819a\u75be\u75c5\u3002\u5176\u75c5\u7406\u7279\u5fb5\u662f\u89d2\u8cea\u5f62\u6210\u7d30\u80de\u904e\u5ea6\u589e\u751f\u3001\u708e\u75c7\u7d30\u80de\u6d78\u6f64\u3001\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u3002\u7531\u65bc\u514d\u75ab\u7cfb\u7d71\u5931\u8abf\uff0c\u708e\u75c7\u90e8\u4f4d\u6703\u5206\u6ccc\u51fa\u8840\u7ba1\u751f\u6210\u56e0\u5b50\u3002\u800c\u4eba\u9ad4\u8abf\u7bc0\u4fee\u5fa9\u7cfb\u7d71\u529f\u80fd\u5931\u6548\u5f8c\uff0c\u53c8\u6703\u6709\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u3001\u8868\u76ae\u7d30\u80de\u589e\u751f\u3001\u5c40\u90e8\u6162\u6027\u708e\u75c7\u7684\u73fe\u8c61\uff0c\u5176\u7d50\u679c\u662f\u60a3\u8005\u6709\u6642\u751a\u81f3\u6703\u5168\u8eab\u90fd\u6cdb\u767c\u51fa\u6697\u7d05\u8272\u4fb5\u6f64\u80a5\u539a\u6027\u6591\u584a\u3002<\/p>\r\n  <div class=\"fig_box\">\r\n    <div class=\"fig_title\">\u57163. \u5e79\u766c\u60a3\u8005\u7684\u76ae\u819a<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.heimat-ltd.com\/cn\/wp-content\/uploads\/research_angiogenesis_skin_03.jpg\" alt=\"\u8840\u7ba1\u65b0\u751f\u548c\u725b\u76ae\u766c\" width=\"60%\" height=\"60%\">\r\n  <\/div>\r\n  <div class=\"fig_box\">\r\n    <div class=\"fig_title\">\u57164. \u8840\u7ba1\u65b0\u751f\u548c\u725b\u76ae\u766c<\/div>\r\n    <img decoding=\"async\" src=\"https:\/\/www.heimat-ltd.com\/cn\/wp-content\/uploads\/research_angiogenesis_skin_04.jpg\" alt=\"\u8840\u7ba1\u65b0\u751f\u548c\u725b\u76ae\u766c\">\r\n  <\/div>\r\n  <p>\u725b\u76ae\u766c\u7684\u81f4\u75c5\u539f\u56e0\u73fe\u5728\u9084\u4e0d\u6e05\u695a\uff0c\u53ef\u80fd\u4f86\u81ea\u4e8e\u57fa\u56e0\u6216\u751f\u6d3b\u7fd2\u6163\uff0c\u52a0\u4e0a\u8eab\u9ad4\u67d0\u7a2e\u514d\u75ab\u5931\u8861\u5c0e\u81f4\u767c\u75c5\u3002\u53e6\u5916\uff0c\u60c5\u7dd2\u58d3\u529b\u3001\u9157\u9152\u3001\u5438\u7159\u7b49\u5f8c\u5929\u56e0\u7d20\u4e5f\u662f\u6b64\u75c5\u60e1\u5316\u7684\u539f\u56e0\u3002\u5f9e\u4ee5\u4e0a\u9019\u4e9b\u89c0\u9ede\u51fa\u767c\uff0c\u5c0d\u65bc\u6cbb\u7642\u4f34\u96a8\u6709\u8840\u7ba1\u65b0\u751f\u7684\u6162\u6027\u708e\u75c7\u6027\u76ae\u819a\u75be\u75c5\uff0c\u7814\u767c\u5177\u6709\u6291\u5236\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u4f5c\u7528\u7684\u85e5\u7269\uff0c\u5c07\u662f\u4eca\u5f8c\u85e5\u7269\u7814\u767c\u7684\u65b0\u76ee\u6a19\u3002<\/p>\r\n<\/div><!--details_box-->\r\n<div class=\"details_box\">\r\n  <b>\u53c3\u8003\u6587\u737b<\/b>\r\n  <ol class=\"reference\">\r\n    <li>Velasco P; Lange-Asschenfeldt B. Dermatological aspects of angiogenesis. British Journal of Dermatology 2002 Nov; 147(5): 841-852.<\/li>\r\n    <li>Detmar M; Brown LF; Claffey KP; Yeo KT; Kocher O; Jackman RW; Berse B; Dvorak HF. Overexpression of vascular permeability factor\/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med. 1994 Sep 1;180(3):1141-1146.<\/li>\r\n    <li>Chung JH; Eun HC. Angiogenesis in skin aging and photoaging. J Dermatol 2007 Sep;34(9):593-600.<\/li>\r\n    <li>D. Graceffa; E. Maiani; A. Pace; F. M. Solivetti; F. Elia; C. De Mutiis; C. Bonifati. Psoriatic Arthritis during Treatment with Bevacizumab for Anaplastic Oligodendroglioma. Case Reports in Rheumatology. Volume 2012 (2012). Article ID 208606. doi:10.1155\/2012\/208606.<\/li>\r\n    <li>Kawada S; Ohtani M; Ishii N. Increased oxygen tension attenuates acute ultraviolet-B-induced skin angiogenesis and wrinkle formation. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2). R694-701. doi: 10.1152.<\/li>\r\n    <li>Chung JH; Yano K; Lee MK; Youn CS; Seo JY; Kim KH; Cho KH; Eun HC; Detmar M. Differential Effects of Photoaging vs Intrinsic Aging on the Vascularization of Human Skin. Arch Dermatol. 2002 Nov;138(11):1437-1442.<\/li>\r\n    <li>Kiichiro Yano, Hajimu Oura, and Michael Detmar. Targeted Overexpression of the Angiogenesis InhibitorThrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage. J Invest Dermatol 118:800- 805, 2002.<\/li>\r\n  <\/ol>\r\n<\/div><!--details_box-->\r\n","protected":false},"excerpt":{"rendered":"\u8840\u7ba1\u65b0\u751f\u53ef\u5c0d\u76ae\u819a\u5e36\u4f86\u5404\u7a2e\u751f\u7406\u53ca\u75c5\u7406\u7684\u5f71\u97ff\uff0c\u5982\u76ae\u819a\u8001\u5316\u3001\u66ec\u50b7\u3001\u5275\u50b7\u6cbb\u6108\u3001\u725b\u76ae\u766c\u3001\u6fd5\u75b9\u3001\u8840\u7ba1\u7624\u3001\u8840\u7ba1\u7e96\u7dad\u7624\u3001\u5361\u6ce2\u897f\u8089\u7624\u7b49\u7b49\u3002\u6211\u5011\u7684\u76ae\u819a\u6bcf\u5929\u66b4\u9732\u5728\u65e5\u5149\u4e4b\u4e0b\uff0c\u9577\u671f\u53d7\u5230\u7d2b\u5916\u7dab(UV)\u548c\u7d05\u5916\u7dab\u7684\u523a\u6fc0\uff0c\u800c\u6b63\u662f\u9019\u4e9b\u523a\u6fc0\u5c0e\u81f4\u76ae\u819a\u65b0\u751f\u8840\u7ba1\u7684\u5f62\u6210\u3002","protected":false},"author":52,"featured_media":1534,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[51],"tags":[],"class_list":["post-768","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/comments?post=768"}],"version-history":[{"count":11,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/768\/revisions"}],"predecessor-version":[{"id":1625,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/posts\/768\/revisions\/1625"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/media\/1534"}],"wp:attachment":[{"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/media?parent=768"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/categories?post=768"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/cn\/wp-json\/wp\/v2\/tags?post=768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}