{"id":846,"date":"2013-06-15T07:52:17","date_gmt":"2013-06-14T22:52:17","guid":{"rendered":"http:\/\/www.heimat-ltd.com\/cn\/?p=846"},"modified":"2021-02-23T08:08:16","modified_gmt":"2021-02-22T23:08:16","slug":"maco-lipin","status":"publish","type":"post","link":"https:\/\/www.heimat-ltd.com\/cn\/resources\/maco-lipin.html","title":{"rendered":"Macolipin (\u9bca\u9b5a\u63d0\u53d6\u8102\u8cea)"},"content":{"rendered":"
\"\u8840\u7ba1\u65b0\u751f\u6291\u5236\u7269\u8cea_Macolipin<\/center>\r\n
\r\n

Macolipin\u662f\u5f9e\u9bca\u9b5a\u4e2d\u62bd\u51fa\u7684\u58f9\u7a2e\u7279\u6b8a\u8102\u8cea\u3002\u5b83\u662f\u6291\u5236\u816b\u7624\u7684\u6210\u9577\u4ee5\u53ca\u8f49\u79fb\u7684\u95dc\u9375\u3001\u88ab\u767c\u73fe\u6709\u8457\u5f37\u5927\u7684\u6291\u5236\u8840\u7ba1\u65b0\u751f\u7684\u4f5c\u7528\u3002\u5305\u62ec\u5c0d\u5167\u81df\u8102\u80aa\u578b\u80a5\u6eff\u7665\u5019\u7fa4\uff0c\u725b\u76ae\u766c\uff0c\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\uff0c\u8001\u5e74\u6027\u9ec3\u6591\u8b8a\u6027\u7665\uff0c\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u7665\u4ee5\u53ca\u4ee5\u8001\u5316\u5e36\u4f86\u7684\u76ae\u819a\u5371\u5bb3\u7b49\uff0c\u9019\u4e5f\u610f\u5473\u8457\u6709\u5229\u65bc\u548c\u8840\u7ba1\u65b0\u751f\u76f8\u95dc\u806f\u7684\u75be\u60a3\u3002\u8840\u7ba1\u65b0\u751f\u5c31\u662f\u6307\u8a95\u751f\u51fa\u65b0\u7684\u8840\u7ba1\u3002\u8840\u7ba1\u65b0\u751f\u5c0d\u65bc\u6b63\u5e38\u7684\u8eab\u9ad4\u767c\u80b2\u4ee5\u53ca\u751f\u7406\u6a5f\u80fd\u4f86\u8aaa\u5c6c\u65bc\u5fc5\u9700\u7684\u6a5f\u80fd\u3002\u4f46\u662f\u5982\u679c\u662f\u5c0d\u65bc\u764c\u4ee5\u53ca\u5176\u4ed6\u75be\u60a3\u4f86\u8aaa\u5247\u9700\u963b\u65b7\u3002\u95dc\u65bc\u8840\u7ba1\u65b0\u751f\u8acb\u9ede\u64ca\u9019\u88cf>><\/a><\/p>\r\n<\/div>\r\n\r\n

\r\n

Macolipin\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u65b0\u751f\u7684\u4f5c\u7528<\/h2>\r\n

\u4ee5\u4e0b\u5167\u5bb9\u4f86\u81eaMacolipin\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u65b0\u751f\u7684\u6548\u679c\u5be6\u9a57\u8b49\u660e\u5831\u544a\u4e2d\u7684\u6458\u8981\u9078\u6bb5\uff0c\u8ffd\u8a18\u4e86\u7c21\u55ae\u7684\u89e3\u8aaa\u5167\u5bb9\u3002<\/p>\r\n

\u5f9e\u9bca\u9b5a\u7684\u808c\u8089\u4e2d\u7372\u53d6\u7684\u4e59\u9187\u62bd\u51fa\u7269\uff0c\u7279\u5225\u91dd\u5c0d\u6291\u5236\u8840\u7ba1\u65b0\u751f\u6709\u8457\u5f37\u5927\u7684\u529b\u91cf\u3002\u5728\u7814\u7a76\u6a5f\u95dc\u7684\u5be6\u9a57\u4e2d\uff0c\u8abf\u5236\u4e86\u5305\u542b\u4e86\u8c50\u5bcc\u7684\u4e8c\u5341\u4e8c\u78b3\u516d\u70ef\u9178\u6b50\u7c73\u83043\u8102\u80aa\u9178\u7684\u591a\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u7684\u9bca\u9b5a\u62bd\u51fa\u8102\u8cea\uff08Macolipin\uff09,\u5728\u5be6\u9a57\u4e2d\u4ee55\u03bcg\/ml\u7684\u7a0b\u5ea6\u6291\u5236\u4e8650%\u7684\u8840\u7ba1\u5f62\u6210\u3002\u5728 \u53e3\u670d\u7d66\u4e88Macolipin\u7684\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u4ee5\u9ad4\u91cd1kg\u5927\u7d04\u4f7f\u7528Macolipin17mg\u7684\u7d66\u4e88\u91cf\u53ef\u5faa\u5c0e\u6291\u523650%\u7684\u8840\u7ba1\u65b0\u751f\u3002\u800c\u4e14\u628aMacolipin\u8207\u6a44\u6b16\u6cb9\u4ee51\uff1a9\u7684\u6bd4\u4f8b\u878d\u5408\u958b\uff0c\u8a66\u7ba1\u5be6\u9a57\u5373\u6709\u4e862\u500d\u7684\u529f\u6548\u3002\u7576\u6642\u986f\u793a\u51fa\u4e86\u55ae\u7368\u4f7f\u7528\u6a44\u6b16\u6cb9\u5c0d\u65bc\u8a66\u7ba1\u5be6\u9a57\u548c\u4e3b\u52d5\u8108\u74b0\u6cd5\u5be6\u9a57\u5b8c\u5168\u6c92\u6709\u963b\u7919\u4f5c\u7528\u3002<\/p>\r\n

\u5f9e\u9019\u500b\u5be6\u9a57\u4e2d\uff0cMacolipin\u548c\u6a44\u6b16\u6cb9\u7684\u7d44\u5408\u88ab\u544a\u77e5\u53ef\u6d88\u9664\u50cfVEGF\u548cFGF-2, TGF-\u03b2\u9019\u6a23\u7684\u56e0\u5b50\u5f15\u8d77\u7684\u5c0d\u65bc\u523a\u6fc0\u8840\u7ba1\u65b0\u751f\u7684\u5f71\u97ff\u3002\u6b64\u5916\uff0c\u9019\u4e9b\u6210\u9577\u56e0\u5b50\u58f9\u65e6\u523a\u6fc0\u5230\u816b\u7624\u5c0d\u76f8\u806f\u7684\u4e3b\u8981\u8840\u7ba1\u7cfb\uff0c\u4fbf\u53ef\u4f7f\u816b\u7624\u6210\u9577\uff0c\u8f49\u79fb\u3002\u9019\u58f9\u7cfb\u5217\u7684\u5be6\u9a57\u4ee51\uff1a9\u7684Macolipin\u548c\u6a44\u6b16\u6cb9\u878d\u5408\u7269\uff0c\u5177\u6709\u5f37\u5927\u7684\u6291\u5236\u8840\u7ba1\u65b0\u751f\u4f5c\u7528\uff0c\u555f\u793a\u5176\u5177\u6709\u6539\u5584\u75c5\u614b\u4f5c\u7528\u4e26\u4e14\u662f\u53ef\u53e3\u670d\u7684\u6d3b\u6027\u5929\u7136\u7269\u3002Macolipin\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u65b0\u751f\u4f5c\u7528\u7684\u6a5f\u5236\uff0c\u53ef\u6291\u5236VEGF\u4ee5\u53ca\u5176\u53d7\u5bb9\u9ad4\uff08VEGFR-1\u548cVEGFR-2\uff09\u76f8\u7d50\u5408\uff0c\u53d7\u5bb9\u9ad4\u7684\u4fe1\u865f\u50b3\u8f38\u9014\u5f91\u6291\u5236\u4e86VEGF\u53d7\u5bb9\u9ad4\u916a\u6c28\u57fa\u7684\u78f7\u9178\u5316\u3002\u55ae\u7d14\u7684\u4f86\u8aaa\uff0c\u6839\u64da\u963b\u7919\u6210\u9577\u56e0\u5b50\u7684\u8840\u7ba1\u7c98\u9644\uff0c\u53ef\u4f5c\u70ba\u9810\u9632\u8840\u7ba1\u65b0\u751f\u7684\u4e0b\u58f9\u6b65\u958b\u59cb\u7684\u58f9\u500b\u4fe1\u865f\u3002<\/p>\r\n

\u6839\u64da\u4ee5\u4e0a\u7684\u7d50\u8ad6\uff0c\u5f9e\u7279\u5b9a\u7684\u9bca\u9b5a\u8089\u4e2d\u62bd\u51fa\u7684\u7279\u6b8a\u7684\u8102\u8cea\u7684Macolipin\u7684\u58f9\u7cfb\u5217\u7684\u5be6\u9a57\u7d50\u679c\u770b\u4f86\uff0c\u555f\u793a\u8457Macolipin\u662f\u5929\u7136\u7d20\u6750\u7531\u4f86\uff0c\u53e3\u670d\u7d66\u4e88\u53ef\u80fd\uff0c\u5177\u6709\u6291\u5236\u8840\u7ba1\u65b0\u751f\u6210\u5206\u7684\u50f9\u503c\u3002\u65e5\u672c\u98df\u54c1\u5206\u6790\u7ad9\u591a\u6469\u7814\u7a76\u6240\u5c0dMacolipin\u9032\u884c\u4e86\u5b89\u5168\u6027\u6e2c\u8a66\uff0c\u8b49\u5be6\u4e86\u5176\u7121\u6bd2\u6027\u548c\u7121\u81f4\u7578\u6027\uff0c\u5c0d\u65bc\u61f7\u5b55\u4e2d\u7684\u80ce\u5152\u7684\u6210\u9577\u4e5f\u6c92\u6709\u5f71\u97ff\u3002<\/p>\r\n<\/div>\r\n\r\n

\r\n \u53c3\u8003\u6587\u737b<\/b>\r\n
    \r\n
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  15. Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 1997;272:15442-15451.<\/li>\r\n
  16. Takahashi T; Shibuya M. The 230 kDa mature form of KDR\/Flk- 1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 1997;14:2079-2089.<\/li>\r\n
  17. Esser S; Lampugnani MG; Corada M; Dejana E; Risau W. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 1998;111: 1853-1865.<\/li>\r\n
  18. Barr MP; Byrne AM; Duffy AM; Condron CM; Devocelle M; Harriott P; Bouchier-Hayes DJ; Harmey JH. A peptide corresponding to the neuropilin-1-binding site on VEGF165 induces apoptosis of neuropilin-1-expressing breast tumour cells. Br J Cancer 2005;92:328-333.<\/li>\r\n
  19. Yoshiji H; Gomez DE; Shibuya M; Thorgeirsson UP. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 1996;56: 2013-2016.<\/li>\r\n <\/ol>\r\n<\/div>\r\n\r\n","protected":false},"excerpt":{"rendered":"Macolipin\u662f\u5f9e\u9bca\u9b5a\u4e2d\u62bd\u51fa\u7684\u58f9\u7a2e\u7279\u6b8a\u8102\u8cea\u3002\u5b83\u662f\u6291\u5236\u816b\u7624\u7684\u6210\u9577\u4ee5\u53ca\u8f49\u79fb\u7684\u95dc\u9375\u3001\u88ab\u767c\u73fe\u6709\u8457\u5f37\u5927\u7684\u6291\u5236\u8840\u7ba1\u65b0\u751f\u7684\u4f5c\u7528\u3002","protected":false},"author":52,"featured_media":845,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-846","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resources"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t