{"id":2295,"date":"2009-06-15T17:18:59","date_gmt":"2009-06-15T08:18:59","guid":{"rendered":"https:\/\/www.heimat-ltd.com\/en\/?p=2295"},"modified":"2022-11-30T09:34:39","modified_gmt":"2022-11-30T00:34:39","slug":"2009-jcss34","status":"publish","type":"post","link":"https:\/\/www.heimat-ltd.com\/en\/information\/reports\/2009-jcss34.html","title":{"rendered":"Transcriptional augmentation of hyaluronan production by Maitake-ethanol extract in human dermal fibroblasts"},"content":{"rendered":"
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Purpose<\/h2>\r\n

Investigation of the effect of maitake mushroom extract on hyaluronic acid production in human skin fibroblasts.<\/p>\r\n<\/div>\r\n

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Results<\/h2>\r\n
    \r\n
  • fibroblasts, Maitake mushroom extract promoted HAS-2 mRNA expression in a concentration-dependent manner<\/li>\r\n
  • The amount of hyaluronic acid in the culture medium increased by maitake mushroom extract treatment due to the promotion of HAS-2 gene expression.<\/li>\r\n
  • This increase in hyaluronic acid was suppressed in a concentration-dependent manner by the hyaluronic acid synthase inhibitor 4-methylumbelliferone.<\/li>\r\n
  • Maitake mushroom extract was found to have no effect on type I collagen a1 and elastin gene expression.<\/li>\r\n
  • Maitake mushroom extract promoted HAS-2 and HAS-3 mRNA expression in human epidermal cells.<\/li>\r\n <\/ul>\r\n<\/div>\r\n
    \r\n

    Discussion<\/h2>\r\n
      \r\n
    • Maitake mushroom extract was found to promote hyaluronic acid production due to increased HAS-2 gene expression in human skin fibroblasts.<\/li>\r\n
    • It was suggested that maitake mushroom extract may be a specific promoter of hyaluronic acid in the regulation of extracellular matrix synthesis in the skin.<\/li>\r\n <\/ul>\r\n<\/div>","protected":false},"excerpt":{"rendered":"Purpose Investigation of the effect of maitake mushroom extract on hyaluronic acid production in human skin fibroblasts. Results fibroblasts, Maitake mushroom extract promoted HAS-2 mRNA expression in a concentration-dependent manner The amount of hyaluronic acid in the culture medium increased by maitake mushroom extract treatment due to the promotion of HAS-2 gene expression. This increase in hyaluronic acid was suppressed in a concentration-dependent manner by the hyaluronic acid synthase inhibitor 4-methylumbelliferone. Maitake mushroom extract was found to have no effect on type I collagen a1 and elastin gene expression. Maitake mushroom extract promoted HAS-2 and HAS-3 mRNA expression in human epidermal cells. Discussion Maitake mushroom extract was found to promote […]","protected":false},"author":98,"featured_media":2297,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[85],"tags":[74],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t