{"id":2295,"date":"2009-06-15T17:18:59","date_gmt":"2009-06-15T08:18:59","guid":{"rendered":"https:\/\/www.heimat-ltd.com\/en\/?p=2295"},"modified":"2022-11-30T09:34:39","modified_gmt":"2022-11-30T00:34:39","slug":"2009-jcss34","status":"publish","type":"post","link":"https:\/\/www.heimat-ltd.com\/en\/information\/reports\/2009-jcss34.html","title":{"rendered":"Transcriptional augmentation of hyaluronan production by Maitake-ethanol extract in human dermal fibroblasts"},"content":{"rendered":"<div class=\"details_box\">\r\n  <h2>Purpose<\/h2>\r\n  <p>Investigation of the effect of maitake mushroom extract on hyaluronic acid production in human skin fibroblasts.<\/p>\r\n<\/div><!--details_box-->\r\n<div class=\"details_box\">\r\n  <h2>Results<\/h2>\r\n  <ul>\r\n    <li>fibroblasts, Maitake mushroom extract promoted HAS-2 mRNA expression in a concentration-dependent manner<\/li>\r\n    <li>The amount of hyaluronic acid in the culture medium increased by maitake mushroom extract treatment due to the promotion of HAS-2 gene expression.<\/li>\r\n    <li>This increase in hyaluronic acid was suppressed in a concentration-dependent manner by the hyaluronic acid synthase inhibitor 4-methylumbelliferone.<\/li>\r\n    <li>Maitake mushroom extract was found to have no effect on type I collagen a1 and elastin gene expression.<\/li>\r\n    <li>Maitake mushroom extract promoted HAS-2 and HAS-3 mRNA expression in human epidermal cells.<\/li>\r\n  <\/ul>\r\n<\/div><!--details_box-->\r\n<div class=\"details_box\">\r\n  <h2>Discussion<\/h2>\r\n  <ul>\r\n    <li>Maitake mushroom extract was found to promote hyaluronic acid production due to increased HAS-2 gene expression in human skin fibroblasts.<\/li>\r\n    <li>It was suggested that maitake mushroom extract may be a specific promoter of hyaluronic acid in the regulation of extracellular matrix synthesis in the skin.<\/li>\r\n  <\/ul>\r\n<\/div><!--details_box-->","protected":false},"excerpt":{"rendered":"Purpose Investigation of the effect of maitake mushroom extract on hyaluronic acid production in human skin fibroblasts. Results fibroblasts, Maitake mushroom extract promoted HAS-2 mRNA expression in a concentration-dependent manner The amount of hyaluronic acid in the culture medium increased by maitake mushroom extract treatment due to the promotion of HAS-2 gene expression. This increase in hyaluronic acid was suppressed in a concentration-dependent manner by the hyaluronic acid synthase inhibitor 4-methylumbelliferone. Maitake mushroom extract was found to have no effect on type I collagen a1 and elastin gene expression. Maitake mushroom extract promoted HAS-2 and HAS-3 mRNA expression in human epidermal cells. Discussion Maitake mushroom extract was found to promote [&hellip;]","protected":false},"author":98,"featured_media":2297,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[85],"tags":[74],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/posts\/2295"}],"collection":[{"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/users\/98"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/comments?post=2295"}],"version-history":[{"count":3,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/posts\/2295\/revisions"}],"predecessor-version":[{"id":2398,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/posts\/2295\/revisions\/2398"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/media\/2297"}],"wp:attachment":[{"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/media?parent=2295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/categories?post=2295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.heimat-ltd.com\/en\/wp-json\/wp\/v2\/tags?post=2295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}