Reports
33rd Annual Meeting of Japanese Cosmetic Science Society, 2008

Improvement of Dry Skin by Topical Treatment of Natural Sebum Inducer

Mie NAGAO, Takashi SATO, Akira ITO, Shigeru MATSUZAKI and Masao TAKAHASHI

Purpose

Sebum secreted by the sebaceous glands plays a role in the biological defense mechanism. Therefore, it is suggested that a decrease in sebum secretion causes a decrease in biological barrier function. In fact, a decrease in sebum secretion with aging causes dry skin, accompanying pruritus is also a factor that causes mental stress. That is to say, substances that promote sebum production are expected to be effective in preventing and improving dry skin. At last year’s meeting, we reported that Grifola frondosa extract (Gripin®) promotes sebum production in hamster sebaceous gland cells in vivo and in vitro. In this study, we investigated the effect of Gripin on improving dry skin in elderly people with mild to severe dry skin based on skin desquamation. Furthermore, we examined the dynamics of sebum and surface water content in the skin of healthy people who applied Gripin®.

Methods

60 men and women with dry skin aged 70 years or older were given 0.2% Gripin® cream to apply on the lower arms and legs once a day for 5weeks. The efficacy of Gripin® was evaluated based on skin desquamation. In addition, 15 healthy men and women aged 20 to 60 years were given 0.2% Gripin® cream or cream substrate on the left forearm 3 times a day for 4 weeks. Epidermal sebum and water content were measured with the Corneometer CM825PC 2 hours after washing the application area.

Results

One week of Gripin® cream applied to elderly people with dry skin improved scales and cracks on the lower leg and dorsal of the feet in most subjects. The effect of 5 weeks of Gripin® cream application was observed to improve symptoms from severe to moderate or moderate to low. In addition, Gripin® cream increased epidermal sebum and water content in healthy subjects. This facilitating effect was observed from the next day of application, and it was found to be persistent.

Related Resources
  • Gripin is a phytolipid compoound extracted from the Maitake mushroom.

    Gripin (Maitake Lipid Extract)


Related Products
  • Maijun Gripin Soap



Raw materials, OEM and PB option at Heimat Co., Japan Ltd
APCGCT: Asia Pacific Consortium of Gene and Cell Therapy
株式会社遺伝子治療研究所
  • Raw materials, OEM and PB option at Heimat Co., Japan Ltd
  • APCGCT: Asia Pacific Consortium of Gene and Cell Therapy
    株式会社遺伝子治療研究所