マイタケ抽出物の皮脂産生促進作用および乾皮症に対する臨床効果

2007年09月05日

2007年9月5日(水)～8日(土)にスイス・チューリッヒのイルチェル大学で開催された37th Annual European Society of Dermatological Research Meeting（第37回ヨーロッパ皮膚科学学会）で、グリピン（マイタケ抽出物）に関する2つの報告がありました。

In Vivo および In Vitroでのマイタケエタノール抽出物による皮脂産生促進作用
Gripin^®(マイタケ抽出物)クリームの乾皮症に対する臨床効果

In Vivo および In Vitroでのマイタケエタノール抽出物による皮脂産生促進作用

Augmentation of Sebaceous Lipogenesis by an Extract of Grifola frondosa (Maitake Mushroom) In Vivo and In Vitro

Takashi Sato¹、Noriko Akimoto¹、Mie Nagao²、Masao Takahashi^2,3、Akira Ito¹

Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences
Heimat Co., Ltd (Japan)
Immuno Research Ltd (New Zealand)

Introduction

Sebaceous lipids (sebum) play an important role in maintaining physiological functions by forming a biological barrier in the skin. The decrease of sebum levels in the skin is thought to depress the barrier functions, and thereafter may be associated with the development of dry skin (xerosis) with a variety of complaints including a rough or scaly skin surface, and pruritus. Therefore, a novel aspect to control sebaceous lipogenesis might be beneficial for the prevention of dry skin and sequential itching. In the present study, we investigated the effects of an ethanol extract of Grifola frondosa (Maitake) fruit body (Gripin^® on sebum production in hamsters and humans and compared these effects with those of an ethanol extract of Agaricus blazei murrill (Agaricus) in vivo and in vitro.

Conclusion

These results provide novel evidence that Gripin^® augments sebaceous lipogenesis in hamsters and humans in vivo and in vitro. Thus, Gripin^® is likely to be a unique anti-dry skin agent with lipogenic actions for sebocytes.

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Gripin^®(マイタケ抽出物)クリームの乾皮症に対する臨床効果

Clinical Trial of Gripin^® Cream (Maitake Mushroom Extract Cream) for Xerosis Therapy

Mie Nagao¹, Shigeru Matsuzaki², Takashi Sato³, Akira Ito³, and Masao Takahashi^1,4

Heimat Co., Ltd (Japan)
Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences
Immuno Research Ltd (New Zealand)

Introduction

Xerosis is defined as dehydration of stratum corneum and characterized by scales, fissures, erosions, and callus in the skin which impairs the skin barrier function. Xerosis is considered to be caused by aging and various environmental factors and is also a common symptom that occurs in chronic skin diseases such as atopic dermatitis. Since patients with xerosis exhibit symptoms, including a scaly and rough skin surface and uncomfortable feeling of itching or pain, effective candidate(s) to structurally and functionally improve the impaired skin barrier may be of benefit to these patients. We have found novel evidence that Grifola frondosa (Maitake mushroom) extract (Gripin^®) facilitates the biosynthesis of sebum, which plays an important role in maintaining the skin barrier, in hamsters and humans in vivo and in vitro (POSTER No. 113). In the present study, to clarify whether or not GripinTM may be effective for xerosis, we performed a clinical trial investigation of 0.2% Gripin^® cream (舞潤^®, MaiJun) in the antebrachial and crural of patients with mild to severe xerosis.

Conclusion

These results suggest that Gripin^® cream is likely to be useful for remission and/or cure of xerosis by the possible mechanism that it augments the level of sebum to restore barrier function in the skin.

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