IID2008(International Investigative Dermatology 2008) May 14-17
An ethanol extract of Grifola frondosa (Maitake mushroom) enhances the anti-angiogenic and anti-tumorigenic actions of polymethoxyflavonoid, nobiletin, in vitro
Takashi Sato1, Mie Nagao2, Masao Takahashi2,3, and Akira Ito1
  1. Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392
  2. Heimat Co., Ltd., Chuo-ku, Tokyo 103-0027, Japan
  3. Immuno Research Ltd., Auckland, New Zealand


Flavonoids from medicinal plants possess pharmacological effects for preventing tumor progression by inhibiting tumor-cell proliferation, neoplastic angiogenesis, and tumor invasion. We reported that a citrus polymethoxyflavonoid, nobiletin (5,6,7,8,3’,4’-hexamethoxy flavone) (Fig.1), exhibits antitumor-invasive and antitumorigenic actions in vivo and in vitro. In addition, water extract of Grifola frondosa (Maitake mushroom) has been reported to possess antitumor effects by enhancing the immune system. However, the anti-angiogenic actions of nobiletin and Maitake mushroom extract remain unclear. In the present study, we examined whether nobiletin and an ethanol extract of the Maitake mushroom (Maitake extract), which is termed Gripin® (Fig. 2), influenced the proliferation of human melanoma Mewo cells and the tube formation of human microvascular endothelial cells (HMVEC).

Raw materials, OEM and PB option at Heimat Co., Japan Ltd
APCGCT: Asia Pacific Consortium of Gene and Cell Therapy