What is Angiogenesis?


Angiogenesis is the term used to describe the development of new blood vessels derived from ‘angio’ meaning blood and ‘genesis’ meaning birth.

About angiogenesis

The phenomenon when networks of new blood vessels are generated.The new blood vessels grow from the existing blood vessels.


Mechanism of angiogenesis

Angiogenesis is an important, natural function in the body responsible for a wide range of activities connected with the circulatory system.

  1. Activating factor of angiogenesis (such as VEGF and MMP) is generated due to growth of cell proliferation, hypoxia condition resulting from infections, blood circulation and deteriorating nutritional condition. angiogenesis02
  2. Basement membrane starts melting, then endothelial cells increase and move. angiogenesis03
  3. New blood vessel is generated by formation of lumen and basement membrane. angiogenesis04

Angiogenesis and related diseases

However, in common with all the other functions in the body, when angiogenesis is overstimulated problems develop and angiogenesis is a “common denominator” shared by diseases affecting more than one billion people worldwide. This includes all cancers, cardiovascular disease, blindness, arthritis, complications of AIDS, diabetes, Alzheimer’s disease, and more than 70 other major health conditions affecting children and adults in developed and developing nations.


Anti-angiogenesis therapies are important mediators in many diseases and research to discover new angiogenesis inhibitors is increasing to the extent that it will have a similar impact in the 21st century to that of antibiotic research in the 20th century.

  1. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9(6), 653-60.
  2. Kristina M. Cook; William D. Figg. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin. 2010 Jul;60(4):222-243.
  3. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995 Jan, 1(1), 27-31.
  4. Li WW, Li VW, Casey R, et al. Clinical trials of angiogenesis-based therapies: overview and new guiding principles, in Angiogenesis: Models, Modulators and Clinical Application. Maragoudakis M, ed. Plenum Press, New York, NY 1998, pp.475-49
  5. The Angiogenesis Foundation
Related Resources
Macolipin is an unique marine derived lipid
Macolipin (Shark Extracted Lipid)

It has strong angiogenesis inhibitory properties which are valuable for inhibiting tumour development and metastasis in cancers and all angiogenesis related disorders including metabolic syndrome, psoriasis, rheumatoid arthritis, macular degeneration, diabetic retinopathy and age related skin disorders.

Related Products
  • Super Maco A contains Macolipin and Flex Seed Oil. To inhibit angiogenesis.
    Super Maco A

    A supplement combined with Shark Lipid (composition of 8 different types of Phospholipid) and Flex Seed Oil. The unique Shark Lipid inhibits angiogenic activity.

  • Ultra Maco contains Macolipin (Marine Lipid) and Egg York Lecithin
    Ultra Maco

    Marine derived lipid and egg yolk lecithin, a combination that supports both health and beauty.

  • A supplement contains Serepen Pigment that is from Saw Palmetto having anti-angiogenesis function by Heilat Co., Ltd in Japan
    Serepen Pigment

    A supplement that contains a pigment extracted from Saw Palmetto. Research has shown that the pigment has anti-angiogenic activity.

Raw materials, OEM and PB option at Heimat Co., Japan Ltd
APCGCT: Asia Pacific Consortium of Gene and Cell Therapy