IID2008 (International Investigative Dermatology 2008) May 14-17
Improvement of skin barrier by a cream containing an ethanol extract of Maitake mushroom on normal and xerosis skin
Mie Nagao1, Takashi Sato2, Akira Ito2, Shigeru Matsuzaki3, and Masao Takahashi1,4
  1. Heimat Co., Ltd., Chuo-ku, Tokyo 103-0027
  2. Department of Biochemistry and Molecular Biology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392
  3. Yoshii Central Clinic, Tano-gun, Gunma 370-2132, Japan
  4. Immuno Research Ltd., Auckland, New Zealand


Xerosis (dry skin) is defined as dehydration of stratum corneum and characterized by scales, fissures, erosion, and calluses on the skin, which thereby impairs the skin barrier function. In addition, most xerosis patients exhibit uncomfortable itching feelings or pain. Thus, structural and functional improvement of the impaired skin barrier may facilitate a treatment for xerosis and improve the quality of life of patients. On the other hand, sebum secreted from sebaceous glands plays an important role for maintaining physiological functions by forming a biological barrier on the skin. Since we found novel evidence that an ethanol extract of Grifola frondosa (Maitake mushroom) fruiting body, which is termed Gripin®, augments the sebum production in hamster sebocytes in vivo and in vitro, the Maitake extract might be an effective means of treating xerosis. In the present study, we performed a clinical trial investigation using a cream containing 0.2% Maitake ethanol extract (Maitake cream) (舞潤®, MaiJun) (Fig. 1) on the posterior antebrachial and crural skin of 60 patients with moderate to severe xerosis, and on the posterior antebrachial skin of healthy volunteers.

Raw materials, OEM and PB option at Heimat Co., Japan Ltd
APCGCT: Asia Pacific Consortium of Gene and Cell Therapy